Allstate Journal

A Guide to Utilize The Powerful Plasticity of Mesenchymal Stem Cells for Widely Application

Mesenchymal stem cells are members of a family of stem cells, which are multipotent stromal cells that have the ability to self-replicate and have strong differentiation potential into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes.

New York – Jan 2nd, 2018 – Creative Bioarray, as a world-leading biotechnology company, specializing in developing unique technologies that provide global scientists with high quality products and satisfactory services. In addition, we also update professional biotechnology knowledge for the popular products we offered. Here you will get a guide to learn about the powerful plasticity of mesenchymal stem cells.

Mesenchymal stem cells are members of a family of stem cells, which are multipotent stromal cells that have the ability to self-replicate and have strong differentiation potential into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes. Meanwhile, mesenchymal stem cells possess the advantage that other stem cells do not have, that is, their unique ability to migrate to injured tissue and regulate the immune response according to the specific environment, which has shown great potential in clinical application. For these characteristics of mesenchymal stem cells, scientists all over the world have conducted in-depth scientific research in the field of mesenchymal stem cells in order to fully understand and recognize its strong plasticity.

Immunomodulatory function of mesenchymal stem cells

The most important feature of mesenchymal stem cells is that they have a strong immunomodulatory effect. Due to the complex and volatile environment in the human body, the immunomodulatory effects of mesenchymal stem cells will be different in distinct inflammatory conditions. Scientists have found that immunomodulation of mesenchymal stem cells has the plasticity that it acts like a mediator of the inflammatory environment: mesenchymal stem cells suppress the immune response when the inflammatory response is enhanced; when the inflammatory response is diminished, Instead, MSCs may promote the immune response.

This characteristic needs great attention in the treatment of the disease. For example, scientists found that mesenchymal stem cells entering the human body can significantly alleviate the condition of patients with cirrhosis, the liver part of the inflammatory response was significantly reduced, liver function indicators such as bilirubin, albumin significantly improved. Hoever, dexamethasone, a steroid hormone immunosuppressive commonly used to treat cirrhosis, counteracts the therapeutic effect of mesenchymal stem cells on cirrhosis to a considerable degree. The reason is that when the patient receives dexamethasone and mesenchymal stem cell combination therapy, the lesion site of liver cirrhosis patients will reduce the inflammation, leading to mesenchymal stem cell immunosuppression weakened and the treatment effect of mesenchymal stem cells may completely disappeare, even making the disease worse. Therefore, the combination of certain drugs with mesenchymal stem cells may undermine the therapeutic effect of mesenchymal stem cells on inflammatory diseases.

Mesenchymal stem cells and tumors

Tumors, which is one of the main factors that will cause to death already make study on the pathogenesis and the exploration of the treatment become the hot spot in biomedical research all over the world.

Tumor is considered a trauma that will never heal, while mesenchymal stem cells, like bullets, can be targeted to migrate to the site of inflammation of the wound, so MSCs can migrate to the tumor site during the growth of the tumor. Scientists use it as a carrier to carry anti-cancer drugs, just as the bullets coated with toxins, so as to achieve effective cancer treatment. As a clinical drug, recombinant interferon alpha (IFN alpha) can treat many kinds of tumors, but its clinical application is limited due to its short half-life, high dosage and serious side effects. To solve this bottleneck problem, scientists ultilize the vector function of mesenchymal stem cells to carry IFN alpha, which enables local release of the cytokine and targeted therapy of tumors. The results showed that mesenchymal stem cells capable of secreting IFN alpha could completely inhibit tumor growth whether co-injected with tumor cells or injected after tumor growth, and their anti-tumor ability was significantly higher than that of IFN alpha recombinant protein.

As a kind of adult stem cell, mesenchymal stem cell has a broad application prospect in the treatment of clinical inflammatory diseases because it has the inherent ability of proliferation and differentiation of stem cells, as well as unique powerful immunomodulatory function. It is believed that in the near future, the mesenchymal stem cells will surely be further explored and controlled by scientists and become a star cell in stem cells, which can be widely used in the clinical treatment of inflammatory diseases.

About Stem Cells Offered by Creative Bioarray:

At Creative Bioarry, we provided the specialized cell culture media and supplements to meet different requirements of your chosen tissue or cell type. In addition, due to the difficulties of isolation and proliferation of stem cells, a package service of stem cell research is available. Our services cover from commercial stem cells for lab use, characterization and differentiation of stem cells to stem cell assay development & screening. In technical bulletin, we provide several protocols for stem cell culture, including human iPSCs, MSCs, CSCs, ESCs. No matter what you want to know about – new to stem cell research, taking your research in a different direction, or just curious about a specific product — we always stay here to provide assistance for you.

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